GMRV Publications

PyramidalExplorer: A New Interactive Tool to Explore Morpho-Functional Relations of Human Pyramidal Neurons

Pablo Toharia, Óscar D. Robles, Isabel Fernaud, Julia Makarova, Sergio E. Galindo, Ángel Rodríguez, Luis Pastor, Oscar Herreras, Javier DeFelipe, Ruth Benavides-Piccione
Frontiers in Neuroanatomy, Volume 9, Number 159 - jan 2016
Download the publication : pyramidalexplorer-publicado.pdf [5.6Mo]  
This work presents PyramidalExplorer, a new tool to interactively explore and reveal the detailed organization of the microanatomy of pyramidal neurons with functionally related models. It consists of a set of functionalities that allow possible regional differences in the pyramidal cell architecture to be interactively discovered by combining quantitative morphological information about the structure of the cell with implemented functional models. The key contribution of this tool is the morpho-functional oriented design that allows the user to navigate within the 3D dataset, filter and perform Content-Based Retrieval operations. As a case study, we present a human pyramidal neuron with over 9000 dendritic spines in its apical and basal dendritic trees. Using PyramidalExplorer, we were able to find unexpected differential morphological attributes of dendritic spines in particular compartments of the neuron, revealing new aspects of the morpho-functional organization of the pyramidal neuron.

Images and movies

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BibTex references

@Article\{TRFMGRPHDB16,
  author       = "Toharia, Pablo and Robles, Óscar D. and Fernaud, Isabel and Makarova, Julia and Galindo, Sergio E. and Rodr\'{\i}guez, Ángel and Pastor, Luis and Herreras, Oscar and DeFelipe, Javier and Benavides-Piccione, Ruth",
  title        = "PyramidalExplorer: A New Interactive Tool to Explore Morpho-Functional Relations of Human Pyramidal Neurons",
  journal      = "Frontiers in Neuroanatomy",
  number       = "159",
  volume       = "9",
  month        = "jan",
  year         = "2016",
  note         = "DOI =10.3389/fnana.2015.00159",
  keywords     = "visual analysis, dendritic spines, cerebral cortex, functional models, 3D reconstructions",
  url          = "http://gmrv.es/Publications/2016/TRFMGRPHDB16"
}

Other publications in the database

» Pablo Toharia
» Óscar D. Robles
» Isabel Fernaud
» Sergio E. Galindo
» Ángel Rodríguez
» Luis Pastor
» Javier DeFelipe
» Ruth Benavides-Piccione